{"entity":{"id":"nct06458712","kind":"trial","name":"Study to Assess Safety, Tolerability and Activity of DSB2455 in Participants With Advanced Malignancies","aka":[],"tldr":"This study tests a PARP inhibitor; the registry reports that it is recruiting.","summary":"The registry lists NCT06458712 as recruiting, last updated 2026-09-02. Enrolment is 180 planned participants, an estimate. Interventions: DSB2455. Primary measures include Number of patients demonstrating dose limiting toxicities and SAEs; Number of patients exhibiting reduction in tumor size.. No results are posted in the registry; this does not exclude separate publications.","status":"recruiting","asOf":"2026-10-06","links":[{"label":"ClinicalTrials.gov NCT06458712","url":"https://clinicaltrials.gov/study/NCT06458712"}],"tags":[],"related":[],"cancers":["breast-cancer","ovarian","prostate","pancreatic"],"sections":[],"technologies":[],"targets":["parp"],"drugs":["dsb2455"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06458712","phase":"1","setting":"Phase Ia/Ib Open Label, Multi-Centre Dose Escalation Study With Expansion Cohorts to Assess the Safety, Tolerability, and Activity of DSB2455 as Monotherapy in Participants With Advanced Malignancies","sponsor":"Duke Street Bio Ltd","participation":[{"nct":"NCT06458712","source":"https://clinicaltrials.gov/study/NCT06458712","fetchedAt":"2026-10-08T16:42:13.801Z","studySha256":"4e2459a49ba8f975f7724af17e963e48713f79f4284f3a0f57e9731861389145","overallStatus":"RECRUITING","lastUpdatePosted":"2026-09-02","leadSponsor":"Duke Street Bio Ltd","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":180,"enrolmentType":"ESTIMATED","siteCount":21,"recruitingSiteCount":21,"countries":["France","Hungary","Poland","Spain","United States"]}],"started":"2024-11-21","startedType":"actual","enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06458712/","neighbours":{"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"target":[{"id":"parp","kind":"target","name":"PARP","route":"/targets/parp/"}],"drug":[{"id":"dsb2455","kind":"drug","name":"DSB2455","route":"/drugs/dsb2455/"}]}}