{"entity":{"id":"nct06453902","kind":"trial","name":"TGRX-678 Chinese Phase II in Chronic Myelogenous Leukemia (CML) Patients","aka":[],"tldr":"A phase 2 trial of TGRX-678 in chronic myeloid leukaemia, run by Shenzhen TargetRx Co., Ltd., now recruiting.","summary":"TGRX-678 Chinese Phase II in Chronic Myelogenous Leukemia (CML) Patients is a phase 2 interventional study registered as NCT06453902 by Shenzhen TargetRx Co., Ltd., with 40 participants planned, started 2024-07-15 and due to reach its primary completion in 2026-06-30. Interventions recorded: TGRX-678.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT06453902","url":"https://clinicaltrials.gov/study/NCT06453902"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["cml","cml-advanced-phase"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["shenzhen-targetrx"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06453902","phase":"2","setting":"A Single-arm, Open-label, Multi-center Phase II Study Evaluating Efficacy and Safety of TGRX-678 in CML-AP Patients Relapsed or Refractory From 3rd-generation TKI Treatment","sponsor":"Shenzhen TargetRx Co., Ltd.","participation":[{"nct":"NCT06453902","source":"https://clinicaltrials.gov/study/NCT06453902","fetchedAt":"2026-10-07T16:54:41.796Z","studySha256":"0623e80b877d70361697ed1a4b0f32c0bba2980bdf406c50420143012ce212d8","overallStatus":"RECRUITING","lastUpdatePosted":"2025-02-21","leadSponsor":"Shenzhen TargetRx Co., Ltd.","collaboratorCount":10,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":40,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":1,"countries":["China"]}],"started":"2024-07-15","startedType":"actual","enrolled":40,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06453902/","neighbours":{"cancer":[{"id":"cml","kind":"cancer","name":"Chronic myeloid leukaemia (CML)","route":"/cancers/cml/"},{"id":"cml-advanced-phase","kind":"cancer","name":"Chronic myeloid leukaemia, accelerated and blast phase","route":"/cancers/cml-advanced-phase/"}],"company":[{"id":"shenzhen-targetrx","kind":"company","name":"Shenzhen TargetRx","route":"/companies/shenzhen-targetrx/"}]}}