{"entity":{"id":"nct06358430","kind":"trial","name":"Dose Escalation and Expansion Study of TROP2 CAR Engineered IL-15- Transduced Cord Blood-derived NK Cells in Combination With Cetuximab in Patient With Colorectal Cancer (CRC) With Minimal Residual Disease (MRD)","aka":[],"tldr":"An early trial studying the safety and activity of experimental treatment. Its registry status does not establish patient benefit.","summary":"Dose Escalation and Expansion Study of TROP2 CAR Engineered IL-15- Transduced Cord Blood-derived NK Cells in Combination With Cetuximab in Patient With Colorectal Cancer (CRC) With Minimal Residual Disease (MRD). ClinicalTrials.gov record last updated 2026-08-04: active not recruiting. Enrollment is actual at 10 participants. Primary completion is estimated at 2029-01-18. No tabular results are posted on ClinicalTrials.gov; this does not exclude separate publications.","status":"active","asOf":"2026-10-06","links":[{"label":"ClinicalTrials.gov NCT06358430","url":"https://clinicaltrials.gov/study/NCT06358430"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":["trop2"],"drugs":["trop2-car-il15-cord-blood-nk","cetuximab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["ClinicalTrials.gov record last updated 2026-08-04: active not recruiting. Enrollment is actual at 10 participants. Primary completion is estimated at 2029-01-18. No tabular results are posted on ClinicalTrials.gov; this does not exclude separate publications."],"nct":"NCT06358430","phase":"1","setting":"Dose Escalation and Expansion Study of TROP2 CAR Engineered IL-15- Transduced Cord Blood-derived NK Cells in Combination With Cetuximab in Patient With Colorectal Cancer (CRC) With Minimal Residual Disease (MRD)","sponsor":"M.D. Anderson Cancer Center","participation":[{"nct":"NCT06358430","source":"https://clinicaltrials.gov/study/NCT06358430","fetchedAt":"2026-10-08T16:42:13.801Z","studySha256":"e4c22bebaa8190b2526fd0de10ce0d6e2d167c4576584384323af318b82b5b28","overallStatus":"ACTIVE_NOT_RECRUITING","lastUpdatePosted":"2026-08-04","leadSponsor":"M.D. Anderson Cancer Center","collaboratorCount":1,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":10,"enrolmentType":"ACTUAL","siteCount":1,"recruitingSiteCount":0,"countries":["United States"]}],"started":"2024-12-02","startedType":"actual","enrolled":10,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06358430/","neighbours":{"target":[{"id":"trop2","kind":"target","name":"TROP2","route":"/targets/trop2/"}],"drug":[{"id":"cetuximab","kind":"drug","name":"Cetuximab","route":"/drugs/cetuximab/"},{"id":"trop2-car-il15-cord-blood-nk","kind":"drug","name":"TROP2 CAR/IL-15 cord-blood NK cells","route":"/drugs/trop2-car-il15-cord-blood-nk/"}]}}