{"entity":{"id":"nct06159478","kind":"trial","name":"Binimetinib in Patients With BRAF Fusion-positive Low-grade Glioma or Pancreatic Cancer (Perfume)","aka":["Perfume"],"tldr":"A phase 2 trial in pancreatic cancer, run by National Cancer Center, Japan, now recruiting.","summary":"Binimetinib in Patients With BRAF Fusion-positive Low-grade Glioma or Pancreatic Cancer (Perfume) is a phase 2, interventional study registered as NCT06159478 by National Cancer Center, Japan, with a registry enrolment figure of 32 participants, started 2023-03-29 and due to reach its primary completion in 2027-02-28. Interventions recorded: Binimetinib 15 MG. Conditions listed: Low-grade Glioma; Pancreatic Cancer. Primary outcome: Overall response rate (centrally assessed). Pancreatic eligibility wording from the registry: \"Cohort B 19) Histopathologically diagnosed as pancreatic cancer (histologically not specified)\". Sites: Japan. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06159478","url":"https://clinicaltrials.gov/study/NCT06159478"}],"tags":["ctgov-ingest","pancreatic-deep-dive"],"related":[],"cancers":["pancreatic","kras-wild-type-pdac"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06159478","phase":"2","setting":"Phase II Investigator-initiated Trial of Binimetinib in Patients With BRAF Fusion-positive Low-grade Glioma or Pancreatic Cancer (Perfume)","sponsor":"National Cancer Center, Japan","participation":[{"nct":"NCT06159478","source":"https://clinicaltrials.gov/study/NCT06159478","fetchedAt":"2026-10-07T16:54:16.815Z","studySha256":"e381d9dadeaaefb894608a8d01c3ce7ed2e64a6897b306c179374425c317101a","overallStatus":"RECRUITING","lastUpdatePosted":"2023-12-13","leadSponsor":"National Cancer Center, Japan","collaboratorCount":1,"minimumAge":"12 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":32,"enrolmentType":"ESTIMATED","siteCount":6,"recruitingSiteCount":6,"countries":["Japan"]}],"started":"2023-03-29","startedType":"actual","enrolled":32,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06159478/","neighbours":{"cancer":[{"id":"kras-wild-type-pdac","kind":"cancer","name":"KRAS wild-type pancreatic ductal adenocarcinoma","route":"/cancers/kras-wild-type-pdac/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"term":[{"id":"pancreatic-trials-open-today","kind":"term","name":"Pancreatic cancer trials open today (registry snapshot and UK sites)","route":"/terms/pancreatic-trials-open-today/"}]}}