{"entity":{"id":"nct06047015","kind":"trial","name":"Irreversible Electroporation (NanoKnife ®) and Immunotherapy for the Treatment of Stage IV Colorectal Cancer","aka":[],"tldr":"A phase 1/2 trial in colorectal cancer, run by University of Saskatchewan, not yet recruiting.","summary":"Irreversible Electroporation (NanoKnife ®) and Immunotherapy for the Treatment of Stage IV Colorectal Cancer is a phase 1/2, interventional study registered as NCT06047015 by University of Saskatchewan, with a registry enrolment figure of 12 participants, started 2025-07 and due to reach its primary completion in 2027-12. Interventions recorded: IRE plus checkpoint inhibitor; IRE plus Checkpoint Inhibitor plus CpG-ODN. Conditions listed: Liver Metastasis Colon Cancer. Primary outcome: Complications; Complications; Abscopal effect: percent change in non-treated colorectal liver metastasis.. Colorectal eligibility wording from the registry: \"Biopsy-proven colorectal liver metastases with at least one measuring \\< 3\". No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06047015","url":"https://clinicaltrials.gov/study/NCT06047015"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06047015","phase":"1/2","setting":"Immune Response to Irreversible Electroporation (NanoKnife ®) and a Checkpoint Inhibitor With or Without CpG Oligodeoxynucleotides for the Treatment of Stage IV Colorectal Cancer","sponsor":"University of Saskatchewan","participation":[{"nct":"NCT06047015","source":"https://clinicaltrials.gov/study/NCT06047015","fetchedAt":"2026-10-07T16:54:07.437Z","studySha256":"afc4741b1ade84d5d34431a2d76dee6e9793b18e18306522313e493ee6e0d0bd","overallStatus":"NOT_YET_RECRUITING","lastUpdatePosted":"2024-08-09","leadSponsor":"University of Saskatchewan","collaboratorCount":0,"minimumAge":"16 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":12,"enrolmentType":"ESTIMATED","siteCount":0,"recruitingSiteCount":0}],"started":"2025-07","startedType":"estimated","enrolled":12,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06047015/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}