{"entity":{"id":"nct06002789","kind":"trial","name":"Safety and Efficacy of PD-1 ± mFOLFOX6 Neoadjuvant Therapy in Local Advanced sMPCC","aka":[],"tldr":"A phase 2 trial in colorectal cancer, run by Sixth Affiliated Hospital, Sun Yat-sen University, now recruiting.","summary":"Safety and Efficacy of PD-1 ± mFOLFOX6 Neoadjuvant Therapy in Local Advanced sMPCC is a phase 2, interventional study registered as NCT06002789 by Sixth Affiliated Hospital, Sun Yat-sen University, with a registry enrolment figure of 17 participants, started 2022-05-01 and due to reach its primary completion in 2027-09-01. Interventions recorded: MSI-H/MSS (dMMR/pMMR) mixed sMPCC: combination of mFOLFOX6+PD-1 monoclonal antibody neoadjuvant therapy; All-MSI-H (dMMR) sMPCC: single-drug PD-1 monoclonal antibody neoadjuvant therapy. Conditions listed: Multiple Cancer; Colorectal Cancer. Primary outcome: pCR rate. Colorectal eligibility wording from the registry: \"Histological confirmation of simultaneous multiple primary colorectal cancer (sMPCC);\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT06002789","url":"https://clinicaltrials.gov/study/NCT06002789"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer","msi-high-colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06002789","phase":"2","setting":"Safety and Efficacy of PD-1 Monoclonal Antibody With or Without mFOLFOX6 Neoadjuvant Therapy in Patients With Local Advanced Deficient Mismatch Repair/Microsatellite Instability-high Synchronous Multiple Primary Colorectal Cancer (sMPCC)","sponsor":"Sixth Affiliated Hospital, Sun Yat-sen University","participation":[{"nct":"NCT06002789","source":"https://clinicaltrials.gov/study/NCT06002789","fetchedAt":"2026-10-07T16:54:05.353Z","studySha256":"8458547cec0a184abfadb6903ef2ac9e4158526c50d62fb8205e0399efd5196a","overallStatus":"RECRUITING","lastUpdatePosted":"2026-04-27","leadSponsor":"Sixth Affiliated Hospital, Sun Yat-sen University","collaboratorCount":0,"minimumAge":"18 Years","maximumAge":"80 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":17,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":1,"countries":["China"]}],"started":"2022-05-01","startedType":"actual","enrolled":17,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct06002789/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"msi-high-colorectal","kind":"cancer","name":"Mismatch-repair deficient (MSI-high) colorectal cancer","route":"/cancers/msi-high-colorectal/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}