{"entity":{"id":"nct05990452","kind":"trial","name":"Phase I/II FIH Study of 9MW2921 in Patients With Advanced Solid Tumors","aka":[],"tldr":"A phase 1/2 trial of 9MW2921 in advanced solid tumours, run by Mabwell (Shanghai) Bioscience Co., Ltd., active and no longer recruiting.","summary":"Phase I/II FIH Study of 9MW2921 in Patients With Advanced Solid Tumors. ClinicalTrials.gov record last updated 2024-11-21: active not recruiting. Enrollment is planned at 261 participants. Primary completion is estimated at 2026-09-01. No tabular results are posted on ClinicalTrials.gov; this does not exclude separate publications. Registered interventions: 9MW2921. Registered primary measures: Dose Limited Toxicity (DLT); Adverse Events and Serious Adverse Events; ORR.","status":"active","asOf":"2026-10-06","links":[{"label":"ClinicalTrials.gov NCT05990452","url":"https://clinicaltrials.gov/study/NCT05990452"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":["trop2"],"drugs":[],"companies":["mabwell-shanghai-bioscience"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["ClinicalTrials.gov record last updated 2024-11-21: active not recruiting. Enrollment is planned at 261 participants. Primary completion is estimated at 2026-09-01. No tabular results are posted on ClinicalTrials.gov; this does not exclude separate publications."],"nct":"NCT05990452","phase":"1/2","setting":"Phase I/II FIH Study of 9MW2921 in Patients With Advanced Solid Tumors","sponsor":"Mabwell (Shanghai) Bioscience Co., Ltd.","participation":[{"nct":"NCT05990452","source":"https://clinicaltrials.gov/study/NCT05990452","fetchedAt":"2026-10-07T16:54:05.353Z","studySha256":"4a17644ba4c01cbebcc1fae6751ad8eab2d1e1b37e109e610fc9a870be1f34d4","overallStatus":"ACTIVE_NOT_RECRUITING","lastUpdatePosted":"2024-11-21","leadSponsor":"Mabwell (Shanghai) Bioscience Co., Ltd.","collaboratorCount":0,"minimumAge":"18 Years","maximumAge":"75 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":261,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":0,"countries":["China"]}],"started":"2023-08-28","startedType":"actual","enrolled":261,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05990452/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"target":[{"id":"trop2","kind":"target","name":"TROP2","route":"/targets/trop2/"}],"company":[{"id":"mabwell-shanghai-bioscience","kind":"company","name":"Mabwell (Shanghai) Bioscience","route":"/companies/mabwell-shanghai-bioscience/"}],"drug":[{"id":"9mw2921","kind":"drug","name":"9MW2921","route":"/drugs/9mw2921/"}]}}