{"entity":{"id":"nct05938270","kind":"trial","name":"A Study to Investigate the Biological Effects of Saruparib (AZD5305), Darolutamide, and in Combination in Men With Newly Diagnosed Prostate Cancer.","aka":[],"tldr":"This study tests a PARP inhibitor; the registry reports that it is completed.","summary":"The registry lists NCT05938270 as completed, last updated 2026-06-30. Enrolment is 113 actual participants. Interventions: Saruparib (AZD5305), Darolutamide, No Treatment. Primary measures include Fold change in % γH2AX positive cells from baseline value in tumour samples. No results are posted in the registry; this does not exclude separate publications.","status":"completed","asOf":"2026-10-06","links":[{"label":"ClinicalTrials.gov NCT05938270","url":"https://clinicaltrials.gov/study/NCT05938270"}],"tags":[],"related":[],"cancers":["prostate"],"sections":[],"technologies":[],"targets":["parp"],"drugs":["saruparib"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05938270","phase":"1","setting":"An Open-label, Randomised, Phase-I, Multi-Centre Study to Investigate the Biological Effects of Saruparib (AZD5305) Alone, Darolutamide Alone, and in Combination Given Prior to Radical Prostatectomy in Men With Newly Diagnosed Prostate Cancer (ASCERTAIN)","sponsor":"AstraZeneca","participation":[{"nct":"NCT05938270","source":"https://clinicaltrials.gov/study/NCT05938270","fetchedAt":"2026-10-08T16:42:13.801Z","studySha256":"e6f80719166b029f0b88cd08e7353d4cf85a7edde75b1d117578e2f2af2458d2","overallStatus":"COMPLETED","lastUpdatePosted":"2026-06-30","leadSponsor":"AstraZeneca","collaboratorCount":0,"minimumAge":"18 Years","sex":"MALE","healthyVolunteers":false,"hasEligibility":true,"enrolment":113,"enrolmentType":"ACTUAL","siteCount":16,"recruitingSiteCount":0,"countries":["Australia","Canada","Netherlands","Spain","United Kingdom","United States"]}],"started":"2023-09-21","startedType":"actual","enrolled":113,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05938270/","neighbours":{"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"target":[{"id":"parp","kind":"target","name":"PARP","route":"/targets/parp/"}],"drug":[{"id":"saruparib","kind":"drug","name":"Saruparib","route":"/drugs/saruparib/"}]}}