{"entity":{"id":"nct05909423","kind":"trial","name":"Combining Intratumoral Flu Vaccine and Systemic Pembrolizumab in Patients With Early pMMR Colorectal Cancer","aka":["FLU-IMMUNE"],"tldr":"A phase 2 trial of pembrolizumab in colorectal cancer, run by Zealand University Hospital, not yet recruiting.","summary":"Combining Intratumoral Flu Vaccine and Systemic Pembrolizumab in Patients With Early pMMR Colorectal Cancer is a phase 2, interventional study registered as NCT05909423 by Zealand University Hospital, with a registry enrolment figure of 21 participants, started 2023-09-01 and due to reach its primary completion in 2025-09-01. Interventions recorded: Influenza vaccine; Pembrolizumab. Conditions listed: Colorectal Cancer. Primary outcome: Pathological response. Colorectal eligibility wording from the registry: \"* Have histologically confirmed localized pMMR stage cT1N0M0 to cT4N2M0 (stage I to III) colorectal adenocarcinoma\". Sites: Denmark. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05909423","url":"https://clinicaltrials.gov/study/NCT05909423"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":["checkpoint-inhibitor","shared-antigen-vaccine"],"targets":[],"drugs":["pembrolizumab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05909423","phase":"2","setting":"Combining Intratumoral Flu Vaccine and Systemic Pembrolizumab in Patients With Early pMMR Colorectal Cancer - the FLU-IMMUNE Trial.","sponsor":"Zealand University Hospital","participation":[{"nct":"NCT05909423","source":"https://clinicaltrials.gov/study/NCT05909423","fetchedAt":"2026-10-07T16:54:00.715Z","studySha256":"033ebb818c6fc2b93bcdeeb2993c93599c01b39f700716f83ddedb7712e3b5a2","overallStatus":"NOT_YET_RECRUITING","lastUpdatePosted":"2023-06-18","leadSponsor":"Zealand University Hospital","collaboratorCount":1,"minimumAge":"18 Years","maximumAge":"99 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":21,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":0,"countries":["Denmark"]}],"started":"2023-09-01","startedType":"estimated","enrolled":21,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05909423/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"},{"id":"shared-antigen-vaccine","kind":"technology","name":"Off-the-shelf cancer vaccines","route":"/technologies/shared-antigen-vaccine/"}],"drug":[{"id":"pembrolizumab","kind":"drug","name":"Pembrolizumab","route":"/drugs/pembrolizumab/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}