{"entity":{"id":"nct05874414","kind":"trial","name":"Combination of GNS561 and Trametinib in Patients With Advanced KRAS Mutated Cholangiocarcinoma","aka":[],"tldr":"A phase 1/2 trial of Trametinib in biliary tract cancer, run by Genfit, now recruiting.","summary":"Combination of GNS561 and Trametinib in Patients With Advanced KRAS Mutated Cholangiocarcinoma is a phase 1/2 interventional study registered as NCT05874414 by Genfit, with 98 participants planned, started 2023-08-21 and due to reach its primary completion in 2027-12. Interventions recorded: GNS561 + Trametinib.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT05874414","url":"https://clinicaltrials.gov/study/NCT05874414"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["cholangiocarcinoma"],"sections":[],"technologies":["kinase-inhibitors"],"targets":[],"drugs":["trametinib"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05874414","phase":"1/2","setting":"Phase 1b/2a Study of GNS561 in Combination With Trametinib in Advanced KRAS Mutated Cholangiocarcinoma","sponsor":"Genfit","participation":[{"nct":"NCT05874414","source":"https://clinicaltrials.gov/study/NCT05874414","fetchedAt":"2026-10-07T16:53:59.307Z","studySha256":"aa61575fcdf9035d618c236716b0f974253280b8ea5d9216ebee91740ad7787e","overallStatus":"RECRUITING","lastUpdatePosted":"2026-07-13","leadSponsor":"Genfit","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":98,"enrolmentType":"ESTIMATED","siteCount":11,"recruitingSiteCount":9,"countries":["Puerto Rico","United States"]}],"started":"2023-08-21","startedType":"actual","enrolled":98,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05874414/","neighbours":{"cancer":[{"id":"cholangiocarcinoma","kind":"cancer","name":"Biliary tract cancer (cholangiocarcinoma)","route":"/cancers/cholangiocarcinoma/"}],"technology":[{"id":"kinase-inhibitors","kind":"technology","name":"Small-molecule kinase inhibitors","route":"/technologies/kinase-inhibitors/"}],"drug":[{"id":"trametinib","kind":"drug","name":"Trametinib","route":"/drugs/trametinib/"}]}}