{"entity":{"id":"nct05706129","kind":"trial","name":"A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, Tolerability, and Efficacy of [177Lu]Lu-DPI-4452 in Participants With Unresectable Locally Advanced or Metastatic Solid Tumors","aka":[],"tldr":"A phase 1/2 trial of [68Ga]Ga-DPI-4452 in renal cell carcinoma, pancreatic ductal adenocarcinoma, colorectal cancer, bladder & urothelial cancer, head and neck squamous cell carcinoma and triple-negative breast cancer, run by Lumara Bio Oncologics GmbH, now recruiting.","summary":"A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, Tolerability, and Efficacy of [177Lu]Lu-DPI-4452 in Participants With Unresectable Locally Advanced or Metastatic Solid Tumors is a phase 1/2 interventional study registered as NCT05706129 by Lumara Bio Oncologics GmbH, with 270 participants planned, started 2023-03-14 and due to reach its primary completion in 2027-06. Interventions recorded: [68Ga]Ga-DPI-4452 and [177Lu]Lu-DPI-4452.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT05706129","url":"https://clinicaltrials.gov/study/NCT05706129"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["rcc","pancreatic","colorectal","urothelial","head-and-neck","tnbc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05706129","phase":"1/2","setting":"A Multicenter, Open-Label, Non-Randomized Phase 1/2 Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, Tolerability, and Efficacy of [177Lu]Lu-DPI-4452 in Patients With Unresectable Locally Advanced or Metastatic Solid Tumors","sponsor":"Lumara Bio Oncologics GmbH","participation":[{"nct":"NCT05706129","source":"https://clinicaltrials.gov/study/NCT05706129","fetchedAt":"2026-10-07T16:53:52.193Z","studySha256":"f7d39a6c72a7693c222bfcf701bc541b842749921218de13e812a7fa9b287682","overallStatus":"RECRUITING","lastUpdatePosted":"2026-08-11","leadSponsor":"Lumara Bio Oncologics GmbH","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":270,"enrolmentType":"ESTIMATED","siteCount":10,"recruitingSiteCount":10,"countries":["Australia","France"]}],"started":"2023-03-14","startedType":"actual","enrolled":270,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05706129/","neighbours":{"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"},{"id":"tnbc","kind":"cancer","name":"Triple-negative breast cancer (TNBC)","route":"/cancers/tnbc/"}]}}