{"entity":{"id":"nct05690945","kind":"trial","name":"A Study of QL1706 in Combination With Chemotherapy in PD-L1-Negative Non-small Cell Lung Cancer","aka":[],"tldr":"A phase 3 trial testing QL1706 in non-small-cell lung cancer, active and no longer recruiting.","summary":"A Study of QL1706 in Combination With Chemotherapy in PD-L1-Negative Non-small Cell Lung Cancer is a phase 3 interventional study registered as NCT05690945, led by Qilu Pharmaceutical, and active but no longer recruiting on the registry. Official title: A Randomised, Double-blind, Multicenter Phase 3 Clinical Study to Evaluate the Efficacy and Safety of QL1706 in Combination With Chemotherapy in First-line PD-L1 Negative, Locally Advanced or Metastatic Non-small Cell Lung Cancer Patients. Planned enrolment is 606 participants (actual). The study started in 2023-02-15 and primary completion is expected in 2029-06. No results have been posted on ClinicalTrials.gov.","status":"active","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov NCT05690945","url":"https://clinicaltrials.gov/study/NCT05690945"}],"tags":["ctgov-ingest"],"related":[],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":["ql1706"],"companies":["qilu-pharmaceutical"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05690945","phase":"3","setting":"A Randomized, Double-blind, Multicenter Phase 3 Clinical Study to Evaluate the Efficacy and Safety of QL1706 in Combination With Chemotherapy in First-line PD-L1 Negative, Locally Advanced or Metastatic Non-small Cell Lung Cancer Patients","sponsor":"Qilu Pharmaceutical","participation":[{"nct":"NCT05690945","source":"https://clinicaltrials.gov/study/NCT05690945","fetchedAt":"2026-10-07T16:53:52.193Z","studySha256":"8a7f8ed03c37551b2ce3429beb921f8214d30d8292d7ab87d186572007a12c77","overallStatus":"ACTIVE_NOT_RECRUITING","lastUpdatePosted":"2025-11-18","leadSponsor":"Qilu Pharmaceutical Co., Ltd.","collaboratorCount":0,"minimumAge":"18 Years","maximumAge":"75 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":606,"enrolmentType":"ACTUAL","siteCount":1,"recruitingSiteCount":0,"countries":["China"]}],"started":"2023-02-15","startedType":"actual","enrolled":606,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05690945/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"drug":[{"id":"ql1706","kind":"drug","name":"QL1706","route":"/drugs/ql1706/"}],"company":[{"id":"qilu-pharmaceutical","kind":"company","name":"Qilu Pharmaceutical","route":"/companies/qilu-pharmaceutical/"}]}}