{"entity":{"id":"nct05378919","kind":"trial","name":"Neoadjuvant Therapy vs Standard Therapy in Locally Advanced Rectal Cancer","aka":["RECTUM2015"],"tldr":"A phase 2 trial of fluorouracil (5-FU) in colorectal cancer, run by Lithuanian University of Health Sciences, now recruiting.","summary":"Neoadjuvant Therapy vs Standard Therapy in Locally Advanced Rectal Cancer is a phase 2, randomised interventional study registered as NCT05378919 by Lithuanian University of Health Sciences, with a registry enrolment figure of 250 participants, started 2015-06-01 and due to reach its primary completion in 2025-06-01. Interventions recorded: Radiotherapy 50 Gy; Fluorouracil/folic acid; Chemotherapy in regimen with Oxaliplatin, fluorouracil, folinic acid (FOLFOX4); Radiotherapy 50 Gy. Conditions listed: Neoadjuvant Therapy in Rectal Cancer, Radiotherapy, FOLFOX. Primary outcome: disease-free survival. Colorectal eligibility wording from the registry: \"* diagnosed with rectal adenocarcinoma;\". Sites: Lithuania. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT05378919","url":"https://clinicaltrials.gov/study/NCT05378919"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["cytotoxic-chemotherapy","imrt-igrt"],"targets":[],"drugs":["fluorouracil"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05378919","phase":"2","setting":"Evaluation and Comparison of the Efficacy of a New Standard Pre-operative Chemotherapy for Stage II and III Colorectal Cancer According to the FOLFOX4 Regimen With Routine Chemoradiation Therapy","sponsor":"Lithuanian University of Health Sciences","participation":[{"nct":"NCT05378919","source":"https://clinicaltrials.gov/study/NCT05378919","fetchedAt":"2026-10-07T16:53:41.225Z","studySha256":"41bca14417ddcb0b05f0285c74476b73b042cc0d03d5eaf9e6f9d73bb16a5982","overallStatus":"RECRUITING","lastUpdatePosted":"2022-05-18","leadSponsor":"Lithuanian University of Health Sciences","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":250,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":1,"countries":["Lithuania"]}],"started":"2015-06-01","startedType":"actual","enrolled":250,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct05378919/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"drug":[{"id":"fluorouracil","kind":"drug","name":"Fluorouracil (5-FU)","route":"/drugs/fluorouracil/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}