{"entity":{"id":"nct04888312","kind":"trial","name":"Safety and Efficacy of Mitazalimab in Combination With Chemotherapy in Pancreatic Cancer Patients","aka":["OPTIMIZE-1"],"tldr":"A phase 1/2 trial of CD40 agonist mitazalimab in combination with chemotherapy in pancreatic ductal adenocarcinoma, run by Alligator Bioscience AB, active and no longer recruiting.","summary":"Safety and Efficacy of Mitazalimab in Combination With Chemotherapy in Pancreatic Cancer Patients is a phase 1/2 interventional study registered as NCT04888312 by Alligator Bioscience AB, with 94 participants enrolled, started 2021-09-17 and due to reach its primary completion in 2026-06-01. Interventions recorded: CD40 agonist mitazalimab in combination with chemotherapy.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT04888312","url":"https://clinicaltrials.gov/study/NCT04888312"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["pancreatic","metastatic-pdac"],"sections":[],"technologies":[],"targets":[],"drugs":["mitazalimab"],"companies":["alligator-bioscience"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04888312","phase":"1/2","setting":"An Open-label Phase 1b/2 Study Assessing the Safety and Efficacy of Mitazalimab in Combination With Chemotherapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma","sponsor":"Alligator Bioscience AB","participation":[{"nct":"NCT04888312","source":"https://clinicaltrials.gov/study/NCT04888312","fetchedAt":"2026-10-07T16:53:30.019Z","studySha256":"1e8bae61dfa186bf7b7bc3dbc6cc94be284705c972aa2a5393536e76c75f6661","overallStatus":"ACTIVE_NOT_RECRUITING","lastUpdatePosted":"2025-10-08","leadSponsor":"Alligator Bioscience AB","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":94,"enrolmentType":"ACTUAL","siteCount":14,"recruitingSiteCount":0,"countries":["Belgium","France","Spain"]}],"started":"2021-09-17","startedType":"actual","enrolled":94,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04888312/","neighbours":{"cancer":[{"id":"metastatic-pdac","kind":"cancer","name":"Metastatic pancreatic ductal adenocarcinoma","route":"/cancers/metastatic-pdac/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"drug":[{"id":"mitazalimab","kind":"drug","name":"Mitazalimab","route":"/drugs/mitazalimab/"}],"company":[{"id":"alligator-bioscience","kind":"company","name":"Alligator Bioscience","route":"/companies/alligator-bioscience/"}]}}