{"entity":{"id":"nct04752722","kind":"trial","name":"LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve","aka":["LEGEND"],"tldr":"A phase 1/2 trial of EG-70 (phase 1) in bladder & urothelial cancer, run by enGene, Inc., now recruiting.","summary":"LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve is a phase 1/2 interventional study registered as NCT04752722 by enGene, Inc., with 350 participants planned, started 2021-04-22 and due to reach its primary completion in 2028-04-30. Interventions recorded: EG-70 (phase 1), EG-70 (phase 2) Master Protocol and Surfactant Bladder Pre-Rinse and EG-70 (Substudy).","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT04752722","url":"https://clinicaltrials.gov/study/NCT04752722"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["urothelial","non-muscle-invasive-bladder-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04752722","phase":"1/2","setting":"A Phase 1/2 Study of EG-70 as an Intravesical Administration to Patients With BCG Unresponsive Non-Muscle Invasive Bladder Cancer (NMIBC) and High-Risk NMIBC Patients Who Are BCG Naïve or Received Incomplete BCG Treatment","sponsor":"enGene, Inc.","participation":[{"nct":"NCT04752722","source":"https://clinicaltrials.gov/study/NCT04752722","fetchedAt":"2026-10-07T16:53:26.644Z","studySha256":"8fa40a8b2ef317a5433c558111971a9f8e4930b5dbefb9245d790c1b23228eb0","overallStatus":"RECRUITING","lastUpdatePosted":"2026-08-07","leadSponsor":"enGene, Inc.","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":350,"enrolmentType":"ESTIMATED","siteCount":102,"recruitingSiteCount":100,"countries":["Australia","Canada","France","Germany","Italy","South Korea","Spain","Taiwan","United Kingdom","United States"]}],"started":"2021-04-22","startedType":"actual","enrolled":350,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04752722/","neighbours":{"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"non-muscle-invasive-bladder-cancer","kind":"cancer","name":"Non-muscle-invasive bladder cancer","route":"/cancers/non-muscle-invasive-bladder-cancer/"}]}}