{"entity":{"id":"nct04657991","kind":"trial","name":"A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma","aka":[],"tldr":"A phase 3 trial of Encorafenib, Binimetinib, Pembrolizumab in melanoma, run by Pfizer, active and no longer recruiting.","summary":"A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma is a phase 3 interventional study registered as NCT04657991 by Pfizer, with 257 participants enrolled, started 2021-01-15 and due to reach its primary completion in 2026-10-30. Interventions recorded: Encorafenib, Binimetinib, Pembrolizumab. Conditions listed: Melanoma. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT04657991","url":"https://clinicaltrials.gov/study/NCT04657991"}],"tags":["ctgov-ingest"],"related":[],"cancers":["melanoma","advanced-melanoma","braf-v600-melanoma"],"sections":[],"technologies":["checkpoint-inhibitor","kinase-inhibitors"],"targets":[],"drugs":["encorafenib","binimetinib","pembrolizumab"],"companies":["pfizer"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":["paper-nct04657991-eur-j-cancer-2024"],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04657991","phase":"3","setting":"A PHASE 3, RANDOMIZED, DOUBLE-BLIND STUDY OF ENCORAFENIB AND BINIMETINIB PLUS PEMBROLIZUMAB VERSUS PLACEBO PLUS PEMBROLIZUMAB IN PARTICIPANTS WITH BRAF V600E/K MUTATION-POSITIVE METASTATIC OR UNRESECTABLE LOCALLY ADVANCED MELANOMA","sponsor":"Pfizer","participation":[{"nct":"NCT04657991","source":"https://clinicaltrials.gov/study/NCT04657991","fetchedAt":"2026-10-07T16:53:24.647Z","studySha256":"b1d72c1d1c1783a5948aae76ddfc61e721f711857cadd415d8680e057ca73532","overallStatus":"ACTIVE_NOT_RECRUITING","lastUpdatePosted":"2026-09-03","leadSponsor":"Pfizer","collaboratorCount":1,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":257,"enrolmentType":"ACTUAL","siteCount":151,"recruitingSiteCount":0,"countries":["Argentina","Austria","Belgium","Brazil","Bulgaria","Canada","Czechia","Finland","France","Germany","Greece","Hungary","Israel","Italy","Mexico","New Zealand","Norway","Poland","Russia","Slovakia","South Africa","Spain","Switzerland","Turkey (Türkiye)","Ukraine","United Kingdom","United States"]}],"started":"2021-01-15","startedType":"actual","enrolled":257,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04657991/","neighbours":{"cancer":[{"id":"advanced-melanoma","kind":"cancer","name":"Advanced melanoma (unresectable stage III and stage IV)","route":"/cancers/advanced-melanoma/"},{"id":"braf-v600-melanoma","kind":"cancer","name":"BRAF V600-mutant melanoma","route":"/cancers/braf-v600-melanoma/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"},{"id":"kinase-inhibitors","kind":"technology","name":"Small-molecule kinase inhibitors","route":"/technologies/kinase-inhibitors/"}],"drug":[{"id":"binimetinib","kind":"drug","name":"Binimetinib","route":"/drugs/binimetinib/"},{"id":"encorafenib","kind":"drug","name":"Encorafenib","route":"/drugs/encorafenib/"},{"id":"pembrolizumab","kind":"drug","name":"Pembrolizumab","route":"/drugs/pembrolizumab/"}],"company":[{"id":"pfizer","kind":"company","name":"Pfizer (incl. Seagen)","route":"/companies/pfizer/"}],"paper":[{"id":"paper-nct04657991-eur-j-cancer-2024","kind":"paper","name":"First-line encorafenib plus binimetinib and pembrolizumab for advanced BRAF V600-mutant melanoma: Safety lead-in results from the randomized phase III STARBOARD study","route":"/key-papers/paper-nct04657991-eur-j-cancer-2024/"}]}}