{"entity":{"id":"nct04458272","kind":"trial","name":"A Study of DS-1001b in Patients With Chemotherapy- and Radiotherapy-Naive IDH1 Mutated WHO Grade II Glioma","aka":[],"tldr":"A phase 2 trial of Safusidenib in glioma & glioblastoma, run by Daiichi Sankyo Co., Ltd., active and no longer recruiting.","summary":"A Study of DS-1001b in Patients With Chemotherapy- and Radiotherapy-Naive IDH1 Mutated WHO Grade II Glioma is a phase 2 interventional study registered as NCT04458272 by Daiichi Sankyo Co., Ltd., with 25 participants enrolled, started 2020-07-08 and due to reach its primary completion in 2023-03-10. Interventions recorded: DS-1001b.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT04458272","url":"https://clinicaltrials.gov/study/NCT04458272"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["glioblastoma","idh-mutant-astrocytoma"],"sections":[],"technologies":[],"targets":[],"drugs":["safusidenib"],"companies":["daiichi-sankyo"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04458272","phase":"2","setting":"A Phase II Study of DS-1001b in Patients With Chemotherapy- and Radiotherapy-naive IDH1 Mutated WHO Grade II Glioma","sponsor":"Daiichi Sankyo Co., Ltd.","participation":[{"nct":"NCT04458272","source":"https://clinicaltrials.gov/study/NCT04458272","fetchedAt":"2026-10-07T16:53:20.581Z","studySha256":"3b6a0dd7faa85bbcf847305804a21089220c25daad13276d3ff2210762a57fc2","overallStatus":"ACTIVE_NOT_RECRUITING","lastUpdatePosted":"2026-10-06","leadSponsor":"Daiichi Sankyo Co., Ltd.","collaboratorCount":0,"minimumAge":"20 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":25,"enrolmentType":"ESTIMATED","siteCount":11,"recruitingSiteCount":0,"countries":["Japan"]}],"started":"2020-07-08","startedType":"actual","enrolled":25,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04458272/","neighbours":{"cancer":[{"id":"idh-mutant-astrocytoma","kind":"cancer","name":"Astrocytoma, IDH-mutant (grades 2 to 4)","route":"/cancers/idh-mutant-astrocytoma/"},{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}],"drug":[{"id":"safusidenib","kind":"drug","name":"Safusidenib","route":"/drugs/safusidenib/"}],"company":[{"id":"daiichi-sankyo","kind":"company","name":"Daiichi Sankyo","route":"/companies/daiichi-sankyo/"}]}}