{"entity":{"id":"nct04329728","kind":"trial","name":"The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies","aka":["OPAL"],"tldr":"A phase 1/2 trial of AVM0703 in advanced solid tumours, run by AVM Biotechnology Inc, now recruiting.","summary":"The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies is a phase 1/2 interventional study registered as NCT04329728 by AVM Biotechnology Inc, with 144 participants planned, started 2020-11-06 and due to reach its primary completion in 2027-11-30. Interventions recorded: AVM0703.","status":"recruiting","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT04329728","url":"https://clinicaltrials.gov/study/NCT04329728"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["medpace"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04329728","phase":"1/2","setting":"An Open Label, Phase 1/2 Study Evaluating Immunomodulatory AVM0703 in Patients With Lymphoid Malignancies (OPAL Study)","sponsor":"AVM Biotechnology Inc","participation":[{"nct":"NCT04329728","source":"https://clinicaltrials.gov/study/NCT04329728","fetchedAt":"2026-10-07T16:53:18.074Z","studySha256":"ae7f8522b9c592e59d24125b02c8d6ffea9b967b262440ec37d76544f6e80a3a","overallStatus":"RECRUITING","lastUpdatePosted":"2026-04-15","leadSponsor":"AVM Biotechnology Inc","collaboratorCount":1,"minimumAge":"12 Years","maximumAge":"95 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":144,"enrolmentType":"ESTIMATED","siteCount":11,"recruitingSiteCount":11,"countries":["United States"]}],"started":"2020-11-06","startedType":"actual","enrolled":144,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04329728/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"company":[{"id":"medpace","kind":"company","name":"Medpace","route":"/companies/medpace/"}]}}