{"entity":{"id":"nct04155034","kind":"trial","name":"S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cel","aka":["MAVERICK"],"tldr":"A phase 3 trial in lung cancer, run by SWOG Cancer Research Network, active but no longer recruiting.","summary":"S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer is a phase 3, randomised interventional study registered as NCT04155034 by SWOG Cancer Research Network, with a registry enrolment figure of 668 participants, started 2020-05-04 and due to reach its primary completion in 2026-03-17. Interventions recorded: Magnetic Resonance Imaging; Prophylactic Cranial Irradiation. Conditions listed: Extensive Stage Lung Small Cell Carcinoma; Limited Stage Lung Small Cell Carcinoma; Lung Small Cell Carcinoma. Primary outcome: Overall survival (OS). Lung eligibility wording from the registry: \"* Patient must have a histologically confirmed diagnosis of small-cell lung cancer (SCLC)\". Sites: Canada, Chile, Colombia, Mexico, Saudi Arabia, South Korea, United States. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT04155034","url":"https://clinicaltrials.gov/study/NCT04155034"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["limited-stage-sclc","extensive-stage-sclc"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":["swog"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04155034","phase":"3","setting":"MRI Brain Surveillance Alone Versus MRI Surveillance and Prophylactic Cranial Irradiation (PCI): A Randomized Phase III Trial in Small-Cell Lung Cancer (MAVERICK)","sponsor":"SWOG Cancer Research Network","participation":[{"nct":"NCT04155034","source":"https://clinicaltrials.gov/study/NCT04155034","fetchedAt":"2026-10-07T16:53:14.793Z","studySha256":"89f7ce1a6239880a08683a3d7dc965fae3794fcff5053f28d6ebf7a120a85d73","overallStatus":"ACTIVE_NOT_RECRUITING","lastUpdatePosted":"2026-06-11","leadSponsor":"SWOG Cancer Research Network","collaboratorCount":1,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":668,"enrolmentType":"ESTIMATED","siteCount":446,"recruitingSiteCount":0,"countries":["Canada","Chile","Colombia","Mexico","Saudi Arabia","South Korea","United States"]}],"started":"2020-05-04","startedType":"actual","enrolled":668,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04155034/","neighbours":{"cancer":[{"id":"extensive-stage-sclc","kind":"cancer","name":"Extensive-stage small-cell lung cancer","route":"/cancers/extensive-stage-sclc/"},{"id":"limited-stage-sclc","kind":"cancer","name":"Limited-stage small-cell lung cancer","route":"/cancers/limited-stage-sclc/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"company":[{"id":"swog","kind":"company","name":"SWOG Cancer Research Network","route":"/companies/swog/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}