{"entity":{"id":"nct04090736","kind":"trial","name":"Study to Compare Azacitidine Plus Pevonedistat Versus Azacitidine in Patients With Acute Myeloid Leukemia Not Eligible for Standard Chemotherapy","aka":["PEVOLAM"],"tldr":"A phase 3 trial of Pevonedistat and Azacitidine in Leukaemia, run by PETHEMA Foundation, active and no longer recruiting.","summary":"Study to Compare Azacitidine Plus Pevonedistat Versus Azacitidine in Patients With Acute Myeloid Leukemia Not Eligible for Standard Chemotherapy is a phase 3 interventional study registered as NCT04090736 by PETHEMA Foundation, with 302 participants planned, started 2019-09-24 and due to reach its primary completion in 2023-06-30. Interventions recorded: Pevonedistat, Azacitidine. Conditions recorded: Leukemia, Myeloid, Acute.\n\nLinked to the drug Pevonedistat because the registry names it among its interventions and Leukaemia among its conditions. Registry record only: no result has been read by an editor.","status":"active","asOf":"2026-09-22","links":[{"label":"ClinicalTrials.gov NCT04090736","url":"https://clinicaltrials.gov/study/NCT04090736"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["leukaemia"],"sections":[],"technologies":[],"targets":[],"drugs":["pevonedistat","azacitidine"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT04090736","phase":"3","setting":"A Randomized Phase III, Multicentre, Open Label Clinical Trial Comparing Azacitidine Plus Pevonedistat Versus Azacitidine in Older/Unfit Patients With Newly Diagnosed Acute Myeloid Leukemia Who Are Ineligible for Standard Induction Chemotherapy","sponsor":"PETHEMA Foundation","participation":[{"nct":"NCT04090736","source":"https://clinicaltrials.gov/study/NCT04090736","fetchedAt":"2026-10-07T16:53:14.124Z","studySha256":"1183b754cef39ad7d7ea27708142f651ae1850ebf34d0288064e9d291b14f136","overallStatus":"ACTIVE_NOT_RECRUITING","lastUpdatePosted":"2026-06-25","leadSponsor":"PETHEMA Foundation","collaboratorCount":2,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":302,"enrolmentType":"ACTUAL","siteCount":62,"recruitingSiteCount":0,"countries":["Spain"]}],"started":"2019-09-24","startedType":"actual","enrolled":302,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct04090736/","neighbours":{"cancer":[{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"}],"drug":[{"id":"azacitidine","kind":"drug","name":"Azacitidine","route":"/drugs/azacitidine/"},{"id":"pevonedistat","kind":"drug","name":"Pevonedistat","route":"/drugs/pevonedistat/"}]}}