{"entity":{"id":"nct03875781","kind":"trial","name":"Non Inferiority Study of Preoperative Chemotherapy Without Pelvic Irradiation for Rectal Cancer","aka":["NORAD01"],"tldr":"A phase 3 trial in colorectal cancer, run by Assistance Publique - Hôpitaux de Paris, now recruiting.","summary":"Non Inferiority Study of Preoperative Chemotherapy Without Pelvic Irradiation for Rectal Cancer is a phase 3, randomised interventional study registered as NCT03875781 by Assistance Publique - Hôpitaux de Paris, with a registry enrolment figure of 540 participants, started 2019-06-05 and due to reach its primary completion in 2026-12-05. Interventions recorded: Chemotherapy; Radiochemotherapy. Conditions listed: Rectal Cancer; Advanced Cancer. Primary outcome: Survival. Colorectal eligibility wording from the registry: \"* Histologically proven middle or low rectal carcinoma, ≤ 10 cm from the anal verge on MRI (sagittal slide)\". Sites: France. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT03875781","url":"https://clinicaltrials.gov/study/NCT03875781"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT03875781","phase":"3","setting":"Non Inferiority Multicenter Phase III Randomized Trial Comparing Preoperative Chemotherapy Only to Chemotherapy Followed by Chemoradiotherapy for Locally Advanced Resectable Rectal Cancer (Intergroup FRENCH-GRECCAR- PRODIGE)","sponsor":"Assistance Publique - Hôpitaux de Paris","participation":[{"nct":"NCT03875781","source":"https://clinicaltrials.gov/study/NCT03875781","fetchedAt":"2026-10-07T16:53:10.205Z","studySha256":"ad8c1fafb7f8a3f9197220ff99ba1d0a3ac75a780c27354d1ae16c7461bd01d5","overallStatus":"RECRUITING","lastUpdatePosted":"2026-01-15","leadSponsor":"Assistance Publique - Hôpitaux de Paris","collaboratorCount":0,"minimumAge":"18 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":540,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":1,"countries":["France"]}],"started":"2019-06-05","startedType":"actual","enrolled":540,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct03875781/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}