{"entity":{"id":"nct02448992","kind":"trial","name":"Hippocampal-Sparing Prophylactic Cranial Irradiation in Pathologically Nodal Positive Non-Small-Cell Lung Cancer","aka":[],"tldr":"A phase 2/3 trial in lung cancer, run by Chang Gung Memorial Hospital, now recruiting.","summary":"Hippocampal-Sparing Prophylactic Cranial Irradiation in Pathologically Nodal Positive Non-Small-Cell Lung Cancer is a phase 2/3, randomised interventional study registered as NCT02448992 by Chang Gung Memorial Hospital, with a registry enrolment figure of 90 participants, started 2015-08-01 and due to reach its primary completion in 2026-12-31. Interventions recorded: hippocampal-sparing WBRT. Conditions listed: Non-Small-Cell Lung Cancer (NSCLC); Brain Metastasis. Primary outcome: time to the development of brain metastasis/metastases (BM), irrespective of the absence of active neurological symptoms. Lung eligibility wording from the registry: \"* Clinical diagnosis of NSCLC\". Sites: Taiwan. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-25","links":[{"label":"ClinicalTrials.gov NCT02448992","url":"https://clinicaltrials.gov/study/NCT02448992"}],"tags":["ctgov-ingest","lung-deep-dive"],"related":[],"cancers":["nsclc"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT02448992","phase":"2/3","setting":"Neuropsychological and Oncological Outcomes After Hippocampal-Sparing Prophylactic Cranial Irradiation in Postoperative Patients With Pathologically Nodal Positive Non-Small-Cell Lung Cancer - A Prospective Follow-up Study","sponsor":"Chang Gung Memorial Hospital","participation":[{"nct":"NCT02448992","source":"https://clinicaltrials.gov/study/NCT02448992","fetchedAt":"2026-10-07T16:52:45.434Z","studySha256":"a48023a9369c5c1d7a4a2d134c7188b42a763c704df8b6f2843c757c4d570be1","overallStatus":"RECRUITING","lastUpdatePosted":"2023-05-01","leadSponsor":"Chang Gung Memorial Hospital","collaboratorCount":0,"minimumAge":"18 Years","maximumAge":"80 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":90,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":1,"countries":["Taiwan"]}],"started":"2015-08-01","startedType":"actual","enrolled":90,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct02448992/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"lung-trials-open-today","kind":"term","name":"Lung cancer trials open today (registry snapshot)","route":"/terms/lung-trials-open-today/"}]}}