{"entity":{"id":"nct00003436","kind":"trial","name":"Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myeloid Leukemia","aka":[],"tldr":"A phase 3 trial of Amsacrine, Asparaginase, Cytarabine, Daunorubicin, Etoposide, Methotrexate and Mitoxantrone in Leukaemia and Myelodysplastic syndromes / neoplasms, run by Medical Research Council, completed.","summary":"Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myeloid Leukemia is a phase 3 interventional study registered as NCT00003436 by Medical Research Council, with 2000 participants recorded, started 1998-07. Interventions recorded: amsacrine, asparaginase, cytarabine, daunorubicin hydrochloride, etoposide, methotrexate, mitoxantrone hydrochloride, therapeutic hydrocortisone, allogeneic bone marrow transplantation. Conditions recorded: Leukemia, Myelodysplastic Syndromes.\n\nLinked to the drug Amsacrine because the registry names it among its interventions and Leukaemia and Myelodysplastic syndromes / neoplasms among its conditions. Registry record only: no result has been read by an editor.","status":"completed","asOf":"2026-09-22","links":[{"label":"ClinicalTrials.gov NCT00003436","url":"https://clinicaltrials.gov/study/NCT00003436"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["leukaemia","mds"],"sections":[],"technologies":[],"targets":[],"drugs":["amsacrine","asparaginase","cytarabine","daunorubicin","etoposide","methotrexate","mitoxantrone"],"companies":["mrc-ctu"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT00003436","phase":"3","setting":"Medical Research Council Working Party on Leukaemia in Childhood Acute Myeloid Leukaemia Trial 12","sponsor":"Medical Research Council","participation":[{"nct":"NCT00003436","source":"https://clinicaltrials.gov/study/NCT00003436","fetchedAt":"2026-10-07T16:51:47.921Z","studySha256":"38cfd880a425929f2556650559726e74aa2f2381f3c1d97b9b3a620512825b67","overallStatus":"COMPLETED","lastUpdatePosted":"2013-12-04","leadSponsor":"Medical Research Council","collaboratorCount":0,"maximumAge":"15 Years","sex":"ALL","healthyVolunteers":false,"hasEligibility":true,"enrolment":2000,"enrolmentType":"ESTIMATED","siteCount":1,"recruitingSiteCount":0,"countries":["United Kingdom"]}],"started":"1998-07","enrolled":2000,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct00003436/","neighbours":{"cancer":[{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"mds","kind":"cancer","name":"Myelodysplastic syndromes / neoplasms (MDS)","route":"/cancers/mds/"}],"drug":[{"id":"amsacrine","kind":"drug","name":"Amsacrine","route":"/drugs/amsacrine/"},{"id":"asparaginase","kind":"drug","name":"Asparaginase (pegaspargase, calaspargase pegol, Erwinia asparaginase)","route":"/drugs/asparaginase/"},{"id":"cytarabine","kind":"drug","name":"Cytarabine","route":"/drugs/cytarabine/"},{"id":"daunorubicin","kind":"drug","name":"Daunorubicin","route":"/drugs/daunorubicin/"},{"id":"etoposide","kind":"drug","name":"Etoposide","route":"/drugs/etoposide/"},{"id":"methotrexate","kind":"drug","name":"Methotrexate","route":"/drugs/methotrexate/"},{"id":"mitoxantrone","kind":"drug","name":"Mitoxantrone","route":"/drugs/mitoxantrone/"}],"company":[{"id":"mrc-ctu","kind":"company","name":"MRC Clinical Trials Unit at UCL","route":"/companies/mrc-ctu/"}]}}