{"entity":{"id":"lcb84","kind":"drug","name":"LCB84","aka":[],"tldr":"LCB84 is an experimental antibody-drug conjugate from LigaChem Biosciences. It links an antibody aimed at TROP2 to an MMAE prodrug and is being studied in a phase 1/2 trial.","summary":"LCB84 is a TROP2-directed antibody-drug conjugate developed by LigaChem Biosciences. The NCT05941507 intervention record describes a human monoclonal antibody linked to a monomethyl auristatin E (MMAE) prodrug. This phase 1/2 study evaluates LCB84 alone and with an anti-PD-1 antibody in advanced solid tumours, with estimated enrolment of 300 and estimated primary completion in January 2027. The registry record was last posted on September 24, 2025 and still lists recruiting; this is the registered status, not confirmation that a site has an available slot. No efficacy results are recorded here.","status":"phase-2","asOf":"2026-10-06","links":[{"label":"ClinicalTrials.gov: LCB84 phase 1/2 trial NCT05941507","url":"https://clinicaltrials.gov/study/NCT05941507"},{"label":"Sponsor page","url":"https://www.ligachembio.com"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":["trop2"],"drugs":[],"companies":["ligachem-biosciences"],"institutions":[],"pathways":[],"terms":[],"trials":["nct05941507"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2 + sponsor pipeline pages)","editedOn":"2026-09-11"},"modality":"ADC","mechanism":"TROP2-directed human monoclonal antibody linked to a monomethyl auristatin E (MMAE) prodrug, as described in the NCT05941507 intervention record.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/lcb84/","neighbours":{"target":[{"id":"trop2","kind":"target","name":"TROP2","route":"/targets/trop2/"}],"company":[{"id":"ligachem-biosciences","kind":"company","name":"LigaChem Biosciences","route":"/companies/ligachem-biosciences/"}],"trial":[{"id":"nct05941507","kind":"trial","name":"A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors","route":"/trials/nct05941507/"}]}}