# A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors

Source: https://onco.cc/trials/nct05941507/  
OnCo record `nct05941507` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of LCB84 in advanced solid tumours, run by LigaChem Biosciences, Inc., now recruiting.

## Summary

A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors. ClinicalTrials.gov record last updated 2025-09-24: recruiting. Enrollment is planned at 300 participants. Primary completion is estimated at 2027-01. No tabular results are posted on ClinicalTrials.gov; this does not exclude separate publications. Registered interventions: LCB84, Anti-PD-1 monoclonal antibody. Registered primary measures: Safety of LCB84 alone and LCB84 in combination with an anti-PD-1 Ab (Phase 1 and 2); Recommended Phase 2 Dose of LCB84 alone and LCB84 in combination with an anti-PD-1 Ab (Phase 1); Objective Response Rate (Phase 2).

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-10-06
- Tags: pipeline; ctgov-ingest
- Registry id: NCT05941507
- Phase: 1/2
- Setting: A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors
- Sponsor: LigaChem Biosciences, Inc.
- Enrolled: 300

## Notes

- ClinicalTrials.gov record last updated 2025-09-24: recruiting. Enrollment is planned at 300 participants. Primary completion is estimated at 2027-01. No tabular results are posted on ClinicalTrials.gov; this does not exclude separate publications.

## Sources

- ClinicalTrials.gov NCT05941507: https://clinicaltrials.gov/study/NCT05941507

## Connected records

- cancers: [Metastatic cancer (cancer that has spread)](https://onco.cc/cancers/metastatic-cancer/)
- targets: [TROP2](https://onco.cc/targets/trop2/)
- drugs: [LCB84](https://onco.cc/drugs/lcb84/)
- companies: [LigaChem Biosciences](https://onco.cc/companies/ligachem-biosciences/)

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JSON: https://onco.cc/api/v1/entities/nct05941507.json